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*                        theophylline_project.mlxtran                          *
*                        February 06, 2018 at 15:30:17                         *
*                        Monolix version : 5.0.0                               *
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POPULATION PARAMETERS ESTIMATION _______________________________________________

Fixed Effects ----------------------------    se_lin    rse(%)    pvalue
ka_pop                         :      1.51     0.297      19.6          
V_pop                          :      33.1      1.23      3.73          
beta_V_lw70                    :      0.73     0.277      37.9   0.00838
Cl_pop                         :       2.8     0.201      7.18          
beta_Cl_lw70                   :     0.499     0.544       109     0.359

Standard Deviation of the Random Effects -
omega_ka                       :     0.643     0.143      22.2          
omega_V                        :    0.0885    0.0378      42.7          
omega_Cl                       :     0.237    0.0525      22.1          

Error Model Parameters -------------------
b                              :      0.16    0.0123      7.68          

Elapsed time (seconds) :      1.3
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CORRELATION MATRIX OF THE ESTIMATES ____________________________________________

Fisher by Linearization --------------------------------------------------------
Correlation Matrix :
      ka_pop   1.00000
       V_pop   0.15152   1.00000
 beta_V_lw70  -0.00690   0.05254   1.00000
      Cl_pop   0.00218   0.02396  -0.00447   1.00000
beta_Cl_lw70  -0.00171  -0.00402   0.01264   0.11545   1.00000
    omega_ka   0.00000   0.00000   0.00000   0.00000   0.00000   1.00000
     omega_V   0.00000   0.00000   0.00000   0.00000   0.00000  -0.01882   1.00000
    omega_Cl   0.00000   0.00000   0.00000   0.00000   0.00000   0.00060   0.00226   1.00000
           b   0.00000   0.00000   0.00000   0.00000   0.00000  -0.02124  -0.17896  -0.02731   1.00000
                               min       max   max/min
Eigen values           :      0.82       1.2       1.4

Elapsed time (seconds) :   0.003
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INDIVIDUAL PARAMETERS ESTIMATION _______________________________________________

Individual Parameters Estimation by Conditional Mode ---------------------------
           min        Q1    median        Q3       max
ka :     0.583     0.871      1.39      2.05      5.33
V  :        27        30      32.7      35.1      39.1
Cl :      1.67      2.51      3.07      3.29      3.87

Elapsed time (seconds) :   0.006
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